Study on cytotoxic effects in breast cancer cells can enhance chemotherapeutic effects
A study of the Department of Human Anatomy and Embryology, School of Medicine, Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, together with the Department of Health Sciences, University of Jaén in Spain discovered that the cytotoxic effect of gef gene in breast cancer cells enhances the chemotherapeutic effect of doxorubicin.
The potential use of combined therapy is under intensive study including the association between classical cytotoxic and genes encoding toxic proteins which enhanced the antitumour activity. The main aim of this work was to evaluate whether the gef gene, a suicide gene which has a demonstrated antiproliferative activity in tumour cells, improved the antitumour effect of chemotherapeutic drugs used as first-line treatment in the management of advanced breast cancer.
This therapeutic approach has the potential to overcome some of the major limitations of conventional chemotherapy, and may therefore constitute a promising strategy for future applications in breast cancer therapy.
· * From: Springerlink. Was published on Cancer Chemotherapy and Pharmacology Journal
